{"product_id":"formation-and-cooperative-behaviour-of-protein-complexes-on-the-cell-membrane-springer-theses-3642239870","title":"Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane (Springer Theses)","description":"\u003cp\u003e\u003cstrong\u003eISBN:\u003c\/strong\u003e 3642239870\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAuthor:\u003c\/strong\u003e Guseva, Ksenia\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCondition:\u003c\/strong\u003e New\u003c\/p\u003e\u003cp\u003eWith the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.\u003c\/p\u003e","brand":"Mia Karts","offers":[{"title":"Default Title","offer_id":51904543850784,"sku":"NEW3642239870","price":59.38,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0980\/7426\/3840\/files\/61-3-JzRLGL.jpg?v=1782188639","url":"https:\/\/miakarts.com\/products\/formation-and-cooperative-behaviour-of-protein-complexes-on-the-cell-membrane-springer-theses-3642239870","provider":"Miakarts Books","version":"1.0","type":"link"}