{"product_id":"i-domains-in-integrins-molecular-biology-intelligence-unit-0306478366","title":"I Domains in Integrins (Molecular Biology Intelligence Unit)","description":"\u003cp\u003e\u003cstrong\u003eISBN:\u003c\/strong\u003e 0306478366\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAuthor:\u003c\/strong\u003e Gullberg, Donald\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCondition:\u003c\/strong\u003e New\u003c\/p\u003e\u003cp\u003eIn vertebrates, the integrin family includes 24 members. As the alpha-chains were sequenced, some were observed to have an inserted domain similar to the A domain in several matrix and complement proteins. This inserted ligand binding domain is interactive and was called the I domain in integrins. More recently structural data have shown that an integrin beta-chain also contains an I domain. Nine of the currently known 18 alpha-chains contain an I domain.This book systematically goes through the current knowledge about these integrins, including the newest additions to the integrin family, the collagen-binding alpha10beta1 and alpha11beta1 integrins. The book discusses ligand binding, signalling properties, knock-out phenotypes and possible involvement in disease. This book comprehensively reviews the current knowledge about I domains in integrins and will serve as a useful reference book for scientists in this field.\u003c\/p\u003e","brand":"Mia Karts","offers":[{"title":"Default Title","offer_id":51735444816160,"sku":"NEW0306478366","price":188.89,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0980\/7426\/3840\/files\/515ZNFWLnfL.jpg?v=1779485205","url":"https:\/\/miakarts.com\/products\/i-domains-in-integrins-molecular-biology-intelligence-unit-0306478366","provider":"Miakarts Books","version":"1.0","type":"link"}