{"product_id":"integration-of-pharmaceutical-discovery-and-development-case-histories-pharmaceutical-biotechnology-11-0306457431","title":"Integration of Pharmaceutical Discovery and Development: Case Histories (Pharmaceutical Biotechnology, 11)","description":"\u003cp\u003e\u003cstrong\u003eISBN:\u003c\/strong\u003e 0306457431\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAuthor:\u003c\/strong\u003e Borchardt, Ronald T.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCondition:\u003c\/strong\u003e New\u003c\/p\u003e\u003cp\u003eIn the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic\/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics\/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.\u003c\/p\u003e","brand":"Mia Karts","offers":[{"title":"Default Title","offer_id":51735318724896,"sku":"NEW0306457431","price":206.23,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0980\/7426\/3840\/files\/51mPq3aB88L.jpg?v=1779482077","url":"https:\/\/miakarts.com\/products\/integration-of-pharmaceutical-discovery-and-development-case-histories-pharmaceutical-biotechnology-11-0306457431","provider":"Miakarts Books","version":"1.0","type":"link"}