{"product_id":"klf2-a-master-regulator-of-peripheral-b-lymphocyte-homeostasis-investigations-on-the-function-of-krppel-like-factor-2-klf2-in-b-lymphocytes-german-edition-383812572x","title":"KLF2, a master regulator of peripheral B lymphocyte homeostasis: Investigations on the function of Krppel-like factor 2 (KLF2) in B lymphocytes (German Edition)","description":"\u003cp\u003e\u003cstrong\u003eISBN:\u003c\/strong\u003e 383812572X\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAuthor:\u003c\/strong\u003e Winkelmann, Rebecca\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCondition:\u003c\/strong\u003e New\u003c\/p\u003e\u003cp\u003eLymphocytes play a prominent role in the combat of infectious diseases. For a sufficient but limited immune response it is essential that migration and activation of lymphocytes are strictly controlled. The transcription factor KLF2 modulates T lymphocyte egress from lymphoid organs by regulating S1P1. This is not the case for B cells. Instead, KLF2 regulates homeostasis of B cells in peripheral lymphatic organs and homing of plasma cells to the bone marrow, presumably by controlling the expression of 7 integrin. In mice with a B cell-specific deletion of KLF2, S1P1 expression on B cells was only slightly affected. Accordingly, all splenic B cell subsets were present, but their numbers were increased with a clear bias for marginal zone (MZ) B cells. In contrast, fewer peyers patches harboring less B cells, fewer B1 cells in the peritoneal cavity as well as recirculating B cells in the bone marrow were found. Upon thymus-dependent immunization, IgG titers were diminished and antigen-specific plasma cells were absent in the bone marrow. Furthermore this study provides first evidence that KLF2 is posttranslationally phosphorylated directly or indirectly by the PI3K signaling pathway.\u003c\/p\u003e","brand":"Mia Karts","offers":[{"title":"Default Title","offer_id":51931577647392,"sku":"NEW383812572X","price":72.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/miakarts.com\/products\/klf2-a-master-regulator-of-peripheral-b-lymphocyte-homeostasis-investigations-on-the-function-of-krppel-like-factor-2-klf2-in-b-lymphocytes-german-edition-383812572x","provider":"Miakarts Books","version":"1.0","type":"link"}