{"product_id":"photoreceptors-and-calcium-advances-in-experimental-medicine-and-biology-514-0306474158","title":"Photoreceptors and Calcium (Advances in Experimental Medicine and Biology, 514)","description":"\u003cp\u003e\u003cstrong\u003eISBN:\u003c\/strong\u003e 0306474158\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAuthor:\u003c\/strong\u003e Baehr, Wolfgang\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCondition:\u003c\/strong\u003e New\u003c\/p\u003e\u003cp\u003e2 The role of Ca+ as an internal messenger in visual transduction of vertebrate and invertebrate organisms has been explored intensely in the recent past. Since the 2 early 1970s, calcium ions and cyclic GMP (whose levels are controlled by Ca+ in vertebrates) have been recognized as important second messengers. Particularly in 2 the last decade, however, the role of Ca+ in visual transduction has been re-evalu- ated and a proliferation of research has documented a multiplicity of roles. 2 It is now evident that Ca+ modulates phototransduction by acting at several 2 sites through a host of small Ca+ -binding proteins. For example, in phototransduction 2 of vertebrates, Ca+-free forms of guanylate cyclase activating proteins (GCAPs) activate guanylate cyclase, modulating levels of cOMP, a key event in the return of photoreceptors to pre-bleach conditions. Defects in genes encoding guanylate cy- clase or guanylate cyclase activating proteins lead to severe diseases of the retina (e. g., Leber congenital amaurosis, rod\/cone dystrophy, or cone dystrophy), thus em- phasizing the important role of these proteins in phototransduction. Similarly, mu- 2 tant genes encoding cation or Ca+ channels (cyclic nucleotide-gated cation chan- 2 nels located in the cell membrane and L-type voltage-gated Ca+ channels located at the synapse of photo receptors) lead to retinitis pigmentosa or congenital stationary night blindness. In phototransduction of invertebrate organisms (e. g., Drosophila 2 and Limulus), the role of Ca+ is similarly central, but distinct, from that of vertebrates.\u003c\/p\u003e","brand":"Mia Karts","offers":[{"title":"Default Title","offer_id":51735406248224,"sku":"NEW0306474158","price":245.54,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0980\/7426\/3840\/files\/61nUZjeg3GL.jpg?v=1779483982","url":"https:\/\/miakarts.com\/products\/photoreceptors-and-calcium-advances-in-experimental-medicine-and-biology-514-0306474158","provider":"Miakarts Books","version":"1.0","type":"link"}