{"product_id":"the-polymerase-chain-reaction-0817637508","title":"The Polymerase Chain Reaction","description":"\u003cp\u003e\u003cstrong\u003eISBN:\u003c\/strong\u003e 0817637508\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAuthor:\u003c\/strong\u003e Mullis, Kary B.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eCondition:\u003c\/strong\u003e New\u003c\/p\u003e\u003cp\u003eJames D. Watson When, in late March of 1953, Francis Crick and I came to write the first Nature paper describing the double helical structure of the DNA molecule, Francis had wanted to include a lengthy discussion of the genetic implications of a molecule whose struc ture we had divined from a minimum of experimental data and on theoretical argu ments based on physical principles. But I felt that this might be tempting fate, given that we had not yet seen the detailed evidence from King's College. Nevertheless, we reached a compromise and decided to include a sentence that pointed to the biological significance of the molecule's key feature-the complementary pairing of the bases. \"It has not escaped our notice,\" Francis wrote, \"that the specific pairing that we have postulated immediately suggests a possible copying mechanism for the genetic material.\" By May, when we were writing the second Nature paper, I was more confident that the proposed structure was at the very least substantially correct, so that this second paper contains a discussion of molecular self-duplication using templates or molds. We pointed out that, as a consequence of base pairing, a DNA molecule has two chains that are complementary to each other. Each chain could then act \". . . as a template for the formation on itself of a new companion chain, so that eventually we shall have two pairs of chains, where we only had one before\" and, moreover, \" ...\u003c\/p\u003e","brand":"Mia Karts","offers":[{"title":"Default Title","offer_id":68079199748384,"sku":"NEW0817637508","price":89.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0980\/7426\/3840\/files\/711YfsabTaL.jpg?v=1793497528","url":"https:\/\/miakarts.com\/products\/the-polymerase-chain-reaction-0817637508","provider":"Miakarts Books","version":"1.0","type":"link"}