Dynamic Combinatorial Chemistry: In Drug Discovery, Bioorganic Chemistry, and Materials Science

ISBN: 0470096039

Author: Miller, Benjamin L.

Condition: New

Effective techniques for applying Dynamic Combinatorial ChemistryIn a relatively short period, Dynamic Combinatorial Chemistry (DCC) has grown from proof-of-concept experiments in a few isolated labs to a broad conceptual framework with applications to an exceptional range of problems in molecular recognition, lead compound identification, catalyst design, nanotechnology, polymer science, and others. Bringing together a group of respected experts, this overview explains how chemists can apply DCC and fragment-based library methods to lead generation for drug discovery and molecular recognition in bioorganic chemistry and materials science.Chapters cover:Basic theoryApproaches to binding in proteins and nucleic acidsMolecular recognitionSelf-sortingCatalyst discoveryMaterials discoveryAnalytical chemistry challengesA comprehensive, single-source reference about DCC methods and applications including aspects of fragment-based drug discovery, this is a core reference that will spark the development of new solutions and strategies for chemists building structure libraries and designing compounds and materials.