Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, ...
MIA KARTS BOOKS
Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix
Book Details
- Author
- Earl Prohofsky
- Publisher
- Cambridge University Press
- Format
- Hardcover
- Language
- English
- Category
- Cell Biology
- Condition
- New
- ISBN-13
- 9780521451840
- ISBN-10
- 0521451841
Free U.S. shipping on all orders. International shipping is calculated at checkout.
ISBN: 0521451841
Author: Prohofsky, Earl
Condition: New
This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly cooperative transitions needed to explain helix melting. Prohofsky develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which is then used to determine when the helix melts and how drugs can dissociate from the helix. The author finds melting temperatures to be in excellent agreement with experimental observations.
Have a question?
Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix
